|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The MTHFR rs1801133 polymorphism was not associated with the prognosis of patients with CRC; however, rs1801131 may be associated with the prognosis of patients with CRC.
|
31330573 |
2019 |
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our findings indicated that the rs1801131 polymorphism may serve as a genetic biomarker of HCC in Asians.
|
30917367 |
2019 |
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Further subgroup analyses revealed that the rs1801131</span> polymorphism was significantly associated with the likelihood of HCC in Asians with both FEMs (recessive model: <i>P</i> < 0.0001, OR = 0.42, 95% CI 0.29-0.62; allele model: <i>P</i> = 0.004, OR =1.20, 95% CI 1.06-1.35) and random-effect models (recessive model: <i>P</i> = 0.002, OR = 0.47, 95% CI 0.29-0.75).
|
31282757 |
2019 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
The most significant phosSNPs for SBP, DBP, CAD and IS were rs1801131 in MTHFR, rs3184504 in SH2B3, rs35212307 in WDR12 and rs3184504 in SH2B3, respectively.
|
31456518 |
2019 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP).
|
31815282 |
2019 |
|
Polyp of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
The C/C genotype of MTHFR rs1801131 is more likely to be a genetic risk factor for colorectal polyps in the UK region, although this finding should be verified with a larger sample size.
|
31146742 |
2019 |
|
Ovarian Hyperstimulation Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphic alleles of MTHFR (rs1801131 C-allele and rs1801133 T-allele), AMHR2 (rs2002555 G-allele), and LHCGR (rs2293275 G-allele) were significantly more prevalent among patients with OHSS compared to those in the NOR group.
|
31115963 |
2019 |
|
Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs1801131 and rs1801133 polymorphisms may serve as genetic biomarkers of glaucoma in West Asians.
|
30851082 |
2019 |
|
Deep Vein Thrombosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the MTHFR rs1801133 polymorphism may be implicated in the development of deep vein thrombosis and pulmonary embolism, while the MTHFR rs1801131 polymorphism may contribute to the development of pulmonary embolism.
|
30466296 |
2019 |
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma.
|
31242814 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma.
|
31242814 |
2019 |
|
Thrombophilia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The prevalence of the following genetic variants was determined: F5 c.1601G>A (factor V Leiden), F2 c.*97G>A (factor II or prothrombin mutation), F13A1 (factor XIII) c.103G>T, MTHFR (methylenetetrahydrofolate reductase) c.665C>T and c.1286A>C, as well as PAI-1 (plasminogen activator inhibitor 1) c.-816A>G and c.-844G>A as markers of thrombophilia risk, and *2 and *3 alleles of CYP2C9 (cytochrome P450 2C9) and five variants of VKORC1 (vitamin K epoxide reductase complex subunit 1) as markers of warfarin pharmacogenetics.
|
31187948 |
2019 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
MTHFR-rs1801131-CC genotype was associated with sporadic BC.
|
29544444 |
2018 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
MTHFR-rs1801131-CC genotype was associated with sporadic BC.
|
29544444 |
2018 |
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals.
|
29599316 |
2018 |
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This study demonstrated that MTHFR polymorphism was associated with HCC occurrence and post-transplant HCC recurrence. rs1801131 mutation A to C is a valuable molecular biomarker for predicting HCC occurrence in Chinese Han population.
|
29185200 |
2018 |
|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
MTHFR rs1801131, MTR rs1805087 and BHMT rs3733890 also showed association with ADHD index.
|
29407547 |
2018 |
|
Hyperhomocysteinemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of hyperhomocysteinemia associated MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) was done by PCR-restriction fragment length polymorphism.
|
29600437 |
2018 |
|
Hyperhomocysteinemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MTHFR rs1801133 CT genotype, TT genotype and T allele; the MTHFR rs1801131 AC genotype, CC genotype and C allele; the MTRR rs1801394 GA genotype, GG genotype and G allele; and the MTRR rs162036 AG genotype and AG+GG genotypes were associated with the efficacy of folic acid therapy for HHcy (P<0·05).
|
29644956 |
2018 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our overall analyses suggested that <i>MTRR</i> rs1801394, <i>MTRR</i> rs1532268, <i>MTHFR</i> rs1801131 and <i>MTHFR</i> rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models.
|
30333252 |
2018 |
|
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overall, there was no significant association between <i>MTHFR</i> C677T (rs1801133) or A1298C (rs1801131) polymorphisms and the clinical response to fluoropyrimidine-based chemotherapy under all of the three genetic models (allele model, dominant model, and recessive model) and stratification analysis, except for the retrospective study subgroup in the dominant model of <i>MTHFR</i> C677T and the "5-Fu <i>+</i> FA" treatment group in the allele contrast of <i>MTHFR</i> A1298C.
|
30131855 |
2018 |
|
Vitamin B 12 Deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
On the other hand, the MTHFR c.1286A>C variant did not show significant association with vitamin B12 deficiency in the selected population.
|
30581350 |
2018 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study found that rs1801133, rs1801131 within MTHFR gene, and interaction between C677T and alcohol drinking and haplotype containing the 1298C and 677T alleles were all associated with increased psoriasis risk.
|
30084051 |
2018 |
|
Fanconi Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overall, there was no significant association between <i>MTHFR</i> C677T (rs1801133) or A1298C (rs1801131) polymorphisms and the clinical response to fluoropyrimidine-based chemotherapy under all of the three genetic models (allele model, dominant model, and recessive model) and stratification analysis, except for the retrospective study subgroup in the dominant model of <i>MTHFR</i> C677T and the "5-Fu <i>+</i> FA" treatment group in the allele contrast of <i>MTHFR</i> A1298C.
|
30131855 |
2018 |
|
Exfoliation Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the three SNPs genotyped, MTHFR polymorphisms did not exhibit significant association with PEX (rs1801131; p = 0.549, rs1801133; p = 0.408).
|
28299500 |
2018 |